Description

Order tirzepatide injections online with PayPal.Tirzepatide, sold under the brand names Mounjaro and Zepbound, is an antidiabetic medication used for the treatment of type 2 diabetes^{[8][11][12][13]} and for weight loss.^[9][14] Tirzepatide is administered through subcutaneous injection (under the skin).^[8][11]

The most common side effects include nausea, vomiting, diarrhea, decreased appetite, constipation, upper abdominal discomfort, and abdominal pain.^[8][11][15]

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones involved in blood-sugar control.^[11] After a person has eaten, these hormones are secreted by cells of the intestines, and in turn cause the secretion of insulin. Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood-sugar control.^[11] Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist.^[9]

Tirzepatide was approved for medical use in the United States in May 2022,^[8][11] in the European Union in September 2022,^[10] in Canada in November 2022,^[16] and in Australia in December 2022.^[2] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[17][18] It was approved by the FDA for weight loss in November 2023, under the brand name Zepbound.^[14][19] In November 2023, the UK Medicines and Healthcare products Regulatory Agency revised the indication for tirzepatide to include treatment for weight loss.^[6][20]

Medical uses[edit]

Tirzepatide is indicated to improve blood-sugar control in adults with type 2 diabetes, as an addition to diet and exercise.^[8][11]

Tirzepatide is also indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management.^[9][14]